Exploring the Signs & Symptoms of Myelofibrosis


Each person experiences myelofibrosis differently, with varying symptoms and paths to diagnosis. In early stages, approximately one-third of people impacted by MF do not have symptoms of the disease.

These are not all of the signs and symptoms that people may experience. It is important to keep track of any new or worsening symptoms, and share those with your healthcare provider.





Having a low red blood cell count is called anemia. Your doctor may call it low hemoglobin. Anemia can cause symptoms like:

  • Shortness of breath
  • Tiredness/fatigue
  • Weakness
Enlarged spleen

Enlarged Spleen


Your spleen acts like a filter for your blood. Having an enlarged spleen is called splenomegaly. Splenomegaly can cause symptoms like:

  • Abdominal discomfort
  • Feeling full too quickly
  • Pain under the left ribs
Platelet count

Low Platelet Count


Platelets are important to help your blood clot. Having a low platelet count is called thrombocytopenia. Thrombocytopenia can cause symptoms like:

  • Bleeding easily
  • Bruising easily
  • Bleeding for a long time when cut
Other myelofibrosis symptoms

Other Symptoms


MF can cause different symptoms because it affects the body in many ways. Other symptoms of MF may include:

  • Abdominal pain
  • Difficulty sleeping
  • Inactivity
  • Itchy skin (common in PV)
  • Problems with concentration
  • Weight loss

No matter what symptoms you experience, they can have a significant impact on your daily life. Understanding your symptoms is one way to chart your course with the disease while working with your healthcare provider.

What is Myelofibrosis

What Is Myelofibrosis?

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Doctor with Patient

Arriving at a Diagnosis

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